ICD-10 Code D81.5 | Purine nucleoside phosphorylase [PNP] deficiency Symptoms, Diagnosis, Billing

Purine nucleoside phosphorylase (PNP) deficiency is a rare inherited immunodeficiency disorder caused by mutations in the PNP gene, leading to the accumulation of toxic metabolites that impair lymphocyte function. This condition is clinically significant as it results in severe combined immunodeficiency, increasing susceptibility to infections. The ICD-10 Code D81.5 facilitates accurate diagnosis, documentation, medical billing, and public health reporting, ensuring that affected individuals receive appropriate care and management.

What is ICD-10 Code D81.5 for Purine nucleoside phosphorylase [PNP] deficiency?

ICD-10 Code D81.5 represents Purine nucleoside phosphorylase (PNP) deficiency, a genetic disorder characterized by the inability to properly metabolize purine nucleosides, leading to immunodeficiency. This code should be used in clinical documentation and billing when diagnosing patients with this condition, particularly when they present with recurrent infections or other related complications.

ICD-10 Code D81.5 – Clinical Definition and Explanation of Purine nucleoside phosphorylase [PNP] deficiency

Purine nucleoside phosphorylase (PNP) deficiency is caused by mutations in the PNP gene, leading to impaired purine metabolism and resultant immunodeficiency. The condition typically manifests in infancy or early childhood and requires prompt medical attention to prevent severe infections and complications.

Key Clinical Features:

• Recurrent bacterial, viral, and fungal infections due to immunodeficiency.
• Failure to thrive and developmental delays in affected infants.
• Lymphopenia and elevated levels of toxic metabolites in the blood.
• Potential for autoimmune complications as the disease progresses.

ICD-10 Code D81.5 for Purine nucleoside phosphorylase [PNP] deficiency – SOAP Notes & Clinical Use

ICD-10 Code D81.5 is utilized in SOAP notes to document the clinical presentation, assessment, and treatment of patients with Purine nucleoside phosphorylase deficiency. It plays a crucial role in both acute and chronic care settings, ensuring comprehensive documentation of symptoms and management strategies.

What Does ICD-10 Code D81.5 for Purine nucleoside phosphorylase [PNP] deficiency Mean in SOAP Notes?

In SOAP notes, ICD-10 Code D81.5 connects subjective patient-reported symptoms and objective clinical findings to a formal diagnosis of Purine nucleoside phosphorylase deficiency. This code is essential for ensuring continuity of care, supporting accurate billing, and meeting EHR documentation standards.

Treatment Options for ICD-10 Code D81.5 – Purine nucleoside phosphorylase [PNP] deficiency

Management of Purine nucleoside phosphorylase deficiency is critical to prevent severe infections and complications. Hospitalization may be necessary for severe cases.

Antibiotic Therapy:

• First-line: Intravenous immunoglobulin (IVIG) therapy for infection prevention.
• Alternative: Antibiotics such as trimethoprim-sulfamethoxazole for prophylaxis against Pneumocystis jirovecii pneumonia.
• Duration: Prophylactic antibiotics may be continued until immune function is restored.

Supportive Care:

• Regular monitoring of immune function and infection status.
• Nutritional support to address failure to thrive.
• Vaccination against preventable diseases, considering the immunocompromised state.

Infection Control:

• Strict hygiene measures to prevent infection spread.
• Isolation precautions during outbreaks of infectious diseases.
• Education for caregivers on recognizing early signs of infection.

How to Document Symptoms of Purine nucleoside phosphorylase [PNP] deficiency (ICD-10 D81.5) in SOAP Notes

Subjective:

• Patient reports recurrent infections requiring multiple hospitalizations.
• History of failure to thrive and delayed developmental milestones.
• Family history of immunodeficiency disorders.

Objective:

• Physical examination reveals lymphadenopathy and hepatosplenomegaly.
• Laboratory tests show lymphopenia and elevated uric acid levels.
• Immunological assessment indicates reduced T and B cell counts.

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SOAP Note Guidelines for Diagnosing Purine nucleoside phosphorylase [PNP] deficiency (ICD-10 Code D81.5)

Assessment:

• Diagnosis: Purine nucleoside phosphorylase deficiency, severe immunodeficiency.
• ICD-10 Subcode: D81.5.
• Contributing factors: Genetic mutation leading to impaired purine metabolism.

Plan:

• Initiate IVIG therapy for infection prevention.
• Provide prophylactic antibiotics as indicated.
• Schedule regular follow-up appointments for monitoring immune function.
• Educate family on infection prevention strategies.

Treatment & Plan Section for ICD-10 Code D81.5 – Purine nucleoside phosphorylase [PNP] deficiency

• First-line treatment includes IVIG therapy to boost immune function.
• Prophylactic antibiotics should be prescribed to prevent opportunistic infections.
• Regular monitoring of immune status and nutritional support is essential.
• Patient education on recognizing signs of infection and when to seek care.

Using ICD-10 Code D81.5 for Purine nucleoside phosphorylase [PNP] deficiency in Billing & SOAP Note Compliance

• Ensure accurate documentation of symptoms and clinical findings in SOAP notes.
• Use the code in appropriate clinical settings, including inpatient and outpatient care.
• Align treatment plans with clinical guidelines to support justified billing.
• Document any related complications or comorbidities to enhance coding accuracy.

Related ICD-10 Codes Often Used with Purine nucleoside phosphorylase [PNP] deficiency

• D81.0 – Severe combined immunodeficiency due to adenosine deaminase deficiency
• D81.1 – Severe combined immunodeficiency due to other specified genetic defects
• D81.2 – Severe combined immunodeficiency due to unspecified genetic defect
• D81.3 – X-linked severe combined immunodeficiency

ICD-10 Code D81.5 in Medical Billing and Insurance for Purine nucleoside phosphorylase [PNP] deficiency

ICD-10 Code D81.5 is crucial for billing purposes, particularly in hospital, emergency room, or infectious disease care settings.

Billing Notes:

• Document all relevant clinical findings and treatment plans to support the ICD-10 claim.
• Use the code in conjunction with other relevant codes for comprehensive billing.
• Ensure that the diagnosis is clearly linked to the services provided in the medical record.

Common CPT Pairings: