Severe combined immunodeficiency with low or normal B-cell numbers is a genetic disorder characterized by a significant impairment of the immune system, leading to increased susceptibility to infections. This condition is clinically important as it can result in life-threatening infections and requires prompt diagnosis and intervention. The ICD-10 Code D81.2 facilitates accurate diagnosis, documentation, medical billing, and public health reporting, ensuring that patients receive appropriate care and resources.
ICD-10 Code D81.2 represents Severe combined immunodeficiency with low or normal B-cell numbers, a condition that results from genetic mutations affecting the immune system. This code should be used in clinical documentation and billing when diagnosing patients with this specific immunodeficiency, ensuring proper identification of the underlying disease and facilitating appropriate treatment and management.
Severe combined immunodeficiency with low or normal B-cell numbers is primarily caused by genetic defects that impair the development and function of immune cells, leading to a heightened risk of infections. This condition necessitates immediate medical attention due to its potential for severe complications.
ICD-10 Code D81.2 is utilized in SOAP notes to document the patient's symptoms, assessment findings, and treatment plans. This code is relevant in both acute and chronic care settings, ensuring comprehensive documentation of the patient's immunodeficiency status.
In SOAP notes, ICD-10 Code D81.2 connects subjective patient-reported symptoms and objective clinical findings to a formal diagnosis of severe combined immunodeficiency. This ensures continuity of care, supports accurate billing, and meets EHR documentation standards.
The management of Severe combined immunodeficiency with low or normal B-cell numbers is critical and often requires hospitalization for intensive care.


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| CPT Code | Description |
|---|---|
| 36415 | Collection of venous blood by venipuncture. |
| 96365 | Intravenous infusion, for therapy, prophylaxis, or diagnosis. |
| 90785 | Interactive complexity associated with evaluation and management. |
| 99223 | Initial hospital care, typically 70 minutes or more. |
Common Questions About Using ICD-10 Code D81.2 for Severe combined immunodef w low or normal B-cell numbers
What are the common symptoms of Severe combined immunodeficiency?
Common symptoms include recurrent infections, failure to thrive, and lymphadenopathy. Patients may also experience severe respiratory infections and skin rashes, necessitating prompt medical evaluation.
How is Severe combined immunodeficiency diagnosed?
Diagnosis typically involves clinical evaluation, family history assessment, and laboratory tests to measure immunoglobulin levels and assess immune function. Genetic testing may also be performed.
What treatments are available for Severe combined immunodeficiency?
Treatment options include intravenous immunoglobulin therapy, prophylactic antibiotics, and supportive care. In some cases, hematopoietic stem cell transplantation may be considered.
Is Severe combined immunodeficiency a hereditary condition?
Yes, Severe combined immunodeficiency is often hereditary, resulting from genetic mutations. Family history can play a significant role in the diagnosis and management of the condition.
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