Cytokine release syndrome, grade unspecified, is a systemic inflammatory response triggered by various factors, including infections, autoimmune diseases, and certain therapies such as monoclonal antibodies. This condition is clinically significant due to its potential to cause severe complications, including multi-organ failure. The ICD-10 Code D89.839 facilitates accurate diagnosis, documentation, medical billing, and public health reporting, ensuring that healthcare providers can effectively manage and treat affected patients.
ICD-10 Code D89.839 represents Cytokine release syndrome, grade unspecified, a condition characterized by an excessive immune response leading to systemic inflammation. This syndrome can arise from various underlying diseases or complications, particularly in patients undergoing immunotherapy. The code should be used in clinical documentation and billing when the syndrome is identified, but the specific grade of severity is not determined.
Cytokine release syndrome, grade unspecified, is caused by an overproduction of cytokines, often in response to infections, malignancies, or therapeutic interventions. It can progress rapidly, leading to significant morbidity and necessitating prompt medical attention.
In SOAP notes, ICD-10 Code D89.839 is utilized to document the presence of cytokine release syndrome, capturing symptoms, assessments, and treatment plans. This code is relevant in both acute and chronic care settings, ensuring comprehensive patient management.
ICD-10 Code D89.839 connects subjective patient-reported symptoms and objective clinical findings to a formal diagnosis of cytokine release syndrome. This code is essential for ensuring continuity of care, supporting billing processes, and meeting EHR documentation standards.
Cytokine release syndrome often requires urgent medical intervention, including hospitalization for monitoring and treatment.


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Learn moreICD-10 Code D89.839 is crucial for billing in hospital, ER, or infectious disease care settings, ensuring accurate reimbursement for services rendered.
| CPT Code | Description |
|---|---|
| 99223 | Initial hospital care, typically 70 minutes or more. |
| 36415 | Collection of venous blood by venipuncture. |
| 99232 | Subsequent hospital care, typically 25 minutes. |
Common Questions About Using ICD-10 Code D89.839 for Cytokine release syndrome, grade unspecified
What are the common causes of Cytokine release syndrome?
Cytokine release syndrome can be triggered by infections, autoimmune diseases, and certain therapies, particularly immunotherapies such as monoclonal antibodies. Identifying the underlying cause is crucial for effective management.
How is Cytokine release syndrome treated?
Treatment typically involves supportive care, including fluid resuscitation and oxygen therapy. Corticosteroids may be administered for severe inflammation. The approach may vary based on the underlying cause.
When should ICD-10 Code D89.839 be used?
ICD-10 Code D89.839 should be used when a patient presents with symptoms of cytokine release syndrome, but the specific grade of severity is not determined. It is essential for accurate documentation and billing.
Is Cytokine release syndrome a life-threatening condition?
Yes, cytokine release syndrome can be life-threatening due to its potential to cause multi-organ failure. Prompt recognition and treatment are critical to improving patient outcomes.
Clinical Notes
SOAP notes
DAP notes
AI medical notes