Anemia due to pyruvate kinase deficiency is a rare inherited disorder characterized by a deficiency of the enzyme pyruvate kinase, leading to hemolytic anemia. This condition is clinically significant as it can result in severe anemia, requiring accurate diagnosis and management. The ICD-10 Code D55.21 facilitates precise documentation, billing, and public health reporting, ensuring that healthcare providers can effectively track and manage this condition.
ICD-10 Code D55.21 represents Anemia due to pyruvate kinase deficiency, a genetic disorder that impairs red blood cell metabolism, leading to premature destruction of these cells. This code should be used in clinical documentation and billing when diagnosing patients with this specific type of anemia, ensuring appropriate treatment and management strategies are implemented.
Anemia due to pyruvate kinase deficiency is caused by mutations in the PKLR gene, leading to reduced enzyme activity and subsequent hemolysis of red blood cells. This condition can progress to severe anemia, necessitating medical intervention. Early diagnosis and management are crucial to prevent complications.
ICD-10 Code D55.21 is utilized in SOAP notes to document the patient's symptoms, assessment findings, and treatment plans related to anemia due to pyruvate kinase deficiency. This code is relevant in both acute and chronic care settings, ensuring comprehensive patient management.
In SOAP notes, ICD-10 Code D55.21 connects subjective patient-reported symptoms and objective clinical findings to a formal diagnosis of anemia due to pyruvate kinase deficiency. This ensures continuity of care, supports accurate billing, and meets EHR documentation standards.
Management of anemia due to pyruvate kinase deficiency often requires hospitalization for severe cases. Treatment focuses on supportive care and addressing complications.


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Learn moreICD-10 Code D55.21 is critical in medical billing, particularly in hospital and emergency care settings.
| CPT Code | Description |
|---|---|
| 36430 | Blood transfusion, per unit. |
| 85025 | Complete blood count (CBC) with automated differential. |
| 88305 | Pathology examination of blood smear. |
Common Questions About Using ICD-10 Code D55.21 for Anemia due to pyruvate kinase deficiency
What are the common symptoms of anemia due to pyruvate kinase deficiency?
Common symptoms include fatigue, pallor, jaundice, and splenomegaly. Patients may also experience episodes of shortness of breath and palpitations due to anemia.
How is anemia due to pyruvate kinase deficiency diagnosed?
Diagnosis is typically made through blood tests showing hemolytic anemia, elevated reticulocyte count, and genetic testing to confirm pyruvate kinase deficiency.
What treatment options are available for this condition?
Treatment may include blood transfusions for severe anemia, folic acid supplementation, and splenectomy in recurrent cases to reduce hemolysis.
Is anemia due to pyruvate kinase deficiency hereditary?
Yes, it is an inherited condition caused by mutations in the PKLR gene, and it follows an autosomal recessive inheritance pattern.
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