Refractory cytopenia with multilineage dysplasia and ring sideroblasts is a hematological condition characterized by ineffective hematopoiesis leading to cytopenias in multiple blood cell lines. This condition is clinically significant as it can progress to acute myeloid leukemia (AML). The ICD-10 Code D46.B facilitates accurate diagnosis, documentation, medical billing, and public health reporting, ensuring appropriate management and resource allocation.
ICD-10 Code D46.B represents refractory cytopenia with multilineage dysplasia and ring sideroblasts, a subtype of myelodysplastic syndromes (MDS). This code should be used when documenting cases of cytopenia associated with dysplastic changes in hematopoietic cells and the presence of ring sideroblasts, which are indicative of ineffective erythropoiesis. Accurate coding is essential for clinical documentation and billing purposes.
Refractory cytopenia with multilineage dysplasia and ring sideroblasts is primarily caused by genetic mutations affecting hematopoietic stem cells, leading to ineffective blood cell production. The condition can progress to more severe forms of MDS or acute leukemia, necessitating prompt medical evaluation and intervention.
ICD-10 Code D46.B is utilized in SOAP notes to document the clinical presentation, assessment, and management of patients with refractory cytopenia. It aids in capturing the complexity of the condition, ensuring comprehensive documentation in both acute and chronic care settings.
In SOAP notes, ICD-10 Code D46.B connects subjective patient-reported symptoms and objective clinical findings to a formal diagnosis of refractory cytopenia with multilineage dysplasia and ring sideroblasts. This ensures continuity of care, supports accurate billing, and meets EHR documentation standards.
Management of refractory cytopenia with multilineage dysplasia and ring sideroblasts requires a multidisciplinary approach, often necessitating hospitalization for severe cases.


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Learn moreICD-10 Code D46.B is crucial for billing in hospital and outpatient settings, particularly for hematology and oncology services.
| CPT Code | Description |
|---|---|
| 85025 | Complete blood count with automated differential. |
| 85027 | Complete blood count with manual differential. |
| 88305 | Pathology examination of bone marrow. |
| 36415 | Collection of venous blood by venipuncture. |
Common Questions About Using ICD-10 Code D46.B for Refract cytopenia w multilin dysplasia and ring sideroblasts
What are the common symptoms of refractory cytopenia?
Common symptoms include fatigue, weakness, easy bruising or bleeding, and recurrent infections due to low blood cell counts.
How is refractory cytopenia diagnosed?
Diagnosis is made through blood tests showing cytopenias and a bone marrow biopsy revealing dysplastic changes and ring sideroblasts.
What is the treatment for refractory cytopenia?
Treatment may include blood transfusions, erythropoiesis-stimulating agents, and supportive care to manage symptoms and prevent complications.
Is refractory cytopenia a serious condition?
Yes, it can progress to acute myeloid leukemia, making early diagnosis and management critical.
Clinical Notes
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