Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia characterized by the proliferation of promyelocytes in the bone marrow. It is associated with the presence of the promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) fusion gene, often resulting from a translocation between chromosomes 15 and 17. The condition is clinically significant due to its aggressive nature and potential for severe complications, including coagulopathy. Accurate coding with ICD-10 Code C92.40 is essential for proper diagnosis, documentation, medical billing, and public health reporting.
ICD-10 Code C92.40 represents Acute promyelocytic leukemia, not having achieved remission. This code is used when a patient has been diagnosed with APL but has not responded to treatment, indicating ongoing disease activity. It is crucial for clinical documentation and billing, as it reflects the severity of the disease and the need for continued medical intervention.
Acute promyelocytic leukemia, not having achieved remission, is caused by genetic mutations leading to the accumulation of promyelocytes in the bone marrow. This condition can progress rapidly and requires immediate medical attention to prevent life-threatening complications. The urgency of treatment is underscored by the risk of disseminated intravascular coagulation (DIC) and other severe manifestations.
ICD-10 Code C92.40 is utilized in SOAP notes to document the patient's ongoing symptoms, assessment findings, and treatment plans. It plays a critical role in both acute and chronic care settings, ensuring that the severity of the condition is accurately captured for effective management and billing.
In SOAP notes, ICD-10 Code C92.40 connects subjective reports of symptoms and objective clinical findings to a formal diagnosis of APL that has not achieved remission. This code is essential for ensuring continuity of care, supporting appropriate billing practices, and meeting EHR documentation standards.
The management of Acute promyelocytic leukemia, not having achieved remission, requires urgent intervention to address the aggressive nature of the disease.


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Learn moreICD-10 Code C92.40 is critical for billing purposes, particularly in hospital, emergency room, or infectious disease care settings.
| CPT Code | Description |
|---|---|
| 85025 | Complete blood count with differential. |
| 85027 | Blood count, automated, with platelet count. |
| 36415 | Collection of venous blood by venipuncture. |
| 88305 | Pathology examination of tissue, including bone marrow biopsy. |
Common Questions About Using ICD-10 Code C92.40 for Acute promyelocytic leukemia, not having achieved remission
What are the common symptoms of Acute promyelocytic leukemia?
Common symptoms include fatigue, easy bruising, bleeding, fever, and signs of infection. Patients may also experience pallor and petechiae due to low platelet counts.
How is Acute promyelocytic leukemia treated?
Treatment typically involves chemotherapy with all-trans retinoic acid (ATRA) and arsenic trioxide, along with supportive care to manage complications such as coagulopathy.
When should ICD-10 Code C92.40 be used?
ICD-10 Code C92.40 should be used when a patient is diagnosed with Acute promyelocytic leukemia that has not achieved remission, indicating ongoing disease activity.
What is the significance of documenting this code in EHR?
Documenting ICD-10 Code C92.40 in electronic health records is crucial for accurate billing, continuity of care, and compliance with healthcare regulations.
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