Mixed cellularity Hodgkin lymphoma, spleen is a subtype of Hodgkin lymphoma characterized by a heterogeneous mixture of cell types, including Reed-Sternberg cells. This condition primarily affects the spleen and is significant due to its potential for systemic involvement and progression. Accurate coding with ICD-10 Code C81.27 is essential for proper diagnosis, documentation, medical billing, and public health reporting, ensuring that patients receive appropriate care and resources.
ICD-10 Code C81.27 specifically denotes Mixed cellularity Hodgkin lymphoma affecting the spleen. This code is utilized when documenting cases where the disease presents with a mixture of cellular components, indicating a more complex pathology. It should be applied in clinical documentation and billing when the diagnosis is confirmed through histological examination and when the spleen is involved.
Mixed cellularity Hodgkin lymphoma, spleen is caused by the proliferation of atypical lymphoid cells, including Reed-Sternberg cells, leading to splenic enlargement and potential systemic symptoms. This condition requires prompt medical attention due to its aggressive nature and risk of progression to more advanced stages of lymphoma.
ICD-10 Code C81.27 is integral in SOAP notes for documenting the patient's symptoms, assessment findings, and treatment plans. It aids in ensuring accurate coding for both acute and chronic care settings, facilitating appropriate reimbursement and continuity of care.
In SOAP notes, ICD-10 Code C81.27 connects subjective patient-reported symptoms and objective clinical findings to a formal diagnosis of Mixed cellularity Hodgkin lymphoma, spleen. This code supports continuity of care, justifies billing, and meets EHR documentation standards.
Management of Mixed cellularity Hodgkin lymphoma, spleen often necessitates hospitalization for treatment initiation and monitoring.


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| CPT Code | Description |
|---|---|
| 96413 | Chemotherapy administration, intravenous, push, single or initial substance. |
| 85025 | Complete blood count (CBC) with automated differential. |
| 77014 | Radiologic examination, lymphatic system, for staging. |
Common Questions About Using ICD-10 Code C81.27 for Mixed cellularity Hodgkin lymphoma, spleen
What are the common symptoms of Mixed cellularity Hodgkin lymphoma?
Common symptoms include unexplained weight loss, persistent fever, night sweats, and splenomegaly. Patients may also experience fatigue and generalized pruritus.
How is Mixed cellularity Hodgkin lymphoma diagnosed?
Diagnosis is typically confirmed through a biopsy of affected lymph nodes or spleen, where Reed-Sternberg cells are identified. Imaging studies may also be used for staging.
What treatments are available for Mixed cellularity Hodgkin lymphoma?
Treatment often involves chemotherapy regimens such as ABVD, and may include radiation therapy depending on the stage of the disease. Supportive care is also important.
Is Mixed cellularity Hodgkin lymphoma curable?
Yes, with appropriate treatment, many patients achieve remission. The prognosis depends on various factors, including stage at diagnosis and response to therapy.
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