Overview of CPT Code 22305: Injection of therapeutic substance into joint or bursa
CPT Code 22305 refers to the injection of a therapeutic substance directly into a joint or bursa to alleviate pain, reduce inflammation, or improve joint function. This procedure is commonly used in the management of various musculoskeletal conditions.
When CPT Code 22305 is Used?
This procedure is indicated in several clinical scenarios.
- Osteoarthritis of the knee or hip
- Rheumatoid arthritis flare-ups
- Bursitis in the shoulder or hip
- Tendinitis affecting the elbow or wrist
- Joint effusion requiring therapeutic intervention
Symptoms Indicating This Procedure
Patients may report various symptoms that lead to the consideration of this injection.
- Persistent joint pain during movement or at rest
- Swelling or inflammation around the joint
- Stiffness, especially in the morning or after inactivity
- Limited range of motion in the affected joint
- Pain that worsens with activity
Causes and Risk Factors
Several factors can contribute to the need for this procedure.
- Age-related degeneration of joint tissues
- Previous joint injuries or trauma
- Genetic predisposition to joint diseases
- Obesity, which increases stress on weight-bearing joints
- Repetitive use or overuse of specific joints
Diagnostic Tests Before Procedure
Certain tests may be performed to guide the decision for this injection.
- X-rays to assess joint degeneration or damage
- MRI to evaluate soft tissue structures around the joint
- Ultrasound to visualize joint effusion or inflammation
- Joint aspiration to analyze synovial fluid for infection or crystals
Procedure Description
The injection procedure involves several key steps.
- Patient is positioned comfortably, and the skin over the joint is cleaned with antiseptic.
- Local anesthetic may be applied to minimize discomfort.
- A sterile syringe containing the therapeutic substance is prepared.
- The physician carefully inserts the needle into the joint or bursa using anatomical landmarks or imaging guidance.
- The therapeutic substance is injected, and the needle is withdrawn.
- Pressure is applied to the injection site, and a bandage may be placed.
Preparation for the Procedure
Patients should follow specific guidelines before the injection.
- Inform the physician of any allergies, especially to medications.
- Discuss current medications, particularly blood thinners.
- Avoid taking anti-inflammatory medications for a few days prior, if advised.
- Wear loose-fitting clothing to allow easy access to the injection site.
- Arrange for transportation if sedation is used during the procedure.
Recovery and Aftercare
Post-procedure care is essential for optimal recovery.
- Rest the joint for 24-48 hours after the injection.
- Apply ice to the injection site to reduce swelling.
- Avoid strenuous activities for a few days.
- Follow any prescribed medication regimen, including pain relievers.
- Attend follow-up appointments to monitor progress.
Possible Complications
While generally safe, there are potential risks associated with the procedure.
- Infection at the injection site
- Bleeding or bruising
- Allergic reaction to the injected substance
- Temporary increase in pain or swelling
- Nerve or tissue damage if the needle is improperly placed


Secure, compliant, and built for trust
HIPAA-compliant and designed with privacy in mind, your patient’s data is protected. Focus on care while we safeguard your information.
Learn morePost-Procedure Follow-Up
Monitoring after the procedure is crucial.
- Follow-up visit within 1-2 weeks to assess pain relief and joint function.
- Additional imaging may be required if symptoms persist.
- Regular check-ins to evaluate the need for further treatment or injections.
Alternative Treatments
Several non-surgical options may be considered.
- Physical therapy to strengthen surrounding muscles
- Oral anti-inflammatory medications
- Corticosteroid injections for inflammation
- Hyaluronic acid injections for joint lubrication
- Acupuncture or chiropractic care
Home Care Tips
Patients can take steps at home to aid recovery.
- Keep the injection site clean and dry.
- Use ice packs to manage swelling.
- Engage in gentle range-of-motion exercises as tolerated.
- Stay hydrated and maintain a balanced diet.
- Monitor for any signs of infection or unusual symptoms.
Patient Education & Prevention
Understanding how to prevent joint issues is vital.
- Maintain a healthy weight to reduce joint stress.
- Engage in regular low-impact exercise to strengthen joints.
- Avoid repetitive motions that strain specific joints.
- Incorporate a balanced diet rich in anti-inflammatory foods.
- Stay informed about joint health and seek early treatment for symptoms.
Billing and Coding Information
CPT Code: 22305
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- RT - Right side
- LT - Left side
Average Cost and Insurance Coverage
Costs can vary based on location and insurance.
- Average cost ranges from $200 to $800 per injection.
- Many insurance plans cover the procedure if deemed medically necessary.
- Out-of-pocket costs may apply depending on the insurance policy.
Related CPT Codes