Overview of CPT Code 21601: Excision of benign skin lesion, face, ears, scalp, neck, hands, feet, and genitalia; excised diameter over 4.0 cm
CPT Code 21601 refers to the surgical excision of a benign skin lesion located on the face, ears, scalp, neck, hands, feet, or genitalia, where the excised diameter exceeds 4.0 cm. This procedure is typically performed to remove lesions that may be symptomatic, cosmetically concerning, or have the potential for malignancy.
When CPT Code 21601 is Used?
This code is applicable in various clinical scenarios, including:
- Large benign skin lesions that are symptomatic or causing discomfort.
- Lesions that are cosmetically undesirable and affect the patient's self-esteem.
- Suspicious lesions that require removal for histopathological examination.
- Lesions that have shown signs of growth or change in appearance.
Symptoms Indicating This Procedure
Patients may report the following symptoms that warrant this procedure:
- Visible growth or change in a skin lesion.
- Itching, pain, or tenderness in the area of the lesion.
- Bleeding or oozing from the lesion.
- Lesion size greater than 4.0 cm.
Causes and Risk Factors
Several factors can contribute to the development of benign skin lesions, including:
- Genetic predisposition to skin growths.
- Sun exposure leading to skin changes.
- Chronic irritation or trauma to the skin.
- Certain skin conditions such as seborrheic keratosis or lipomas.
Diagnostic Tests Before Procedure
Before proceeding with the excision, the following diagnostic tests may be conducted:
- Physical examination of the lesion.
- Dermatoscopy to assess the characteristics of the lesion.
- Biopsy if malignancy is suspected.
Procedure Description
The excision procedure typically follows these steps:
- Patient is positioned comfortably and the area is cleaned.
- Local anesthesia is administered to numb the area.
- A surgical incision is made around the lesion, ensuring clear margins.
- The lesion is excised along with a margin of healthy tissue.
- The wound is closed with sutures or adhesive strips.
- Dressing is applied to protect the area.
Preparation for the Procedure
Patients should follow these steps to prepare for the excision:
- Avoid blood thinners and certain medications as advised by the physician.
- Arrive with clean skin, free of lotions or creams.
- Discuss any allergies or medical conditions with the healthcare provider.
- Plan for transportation home post-procedure if sedation is used.
Recovery and Aftercare
Post-procedure recovery typically involves:
- Resting for the remainder of the day after the procedure.
- Keeping the surgical site clean and dry.
- Changing dressings as instructed by the healthcare provider.
- Taking prescribed pain medications as needed.
Possible Complications
While generally safe, this procedure may carry some risks, including:
- Infection at the surgical site.
- Excessive bleeding or hematoma formation.
- Scarring or changes in skin pigmentation.
- Recurrence of the lesion.


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Learn morePost-Procedure Follow-Up
Follow-up care is essential for monitoring recovery:
- Schedule a follow-up appointment within 1-2 weeks to assess healing.
- Monitor for signs of infection or complications.
- Discuss pathology results if the lesion was sent for analysis.
Alternative Treatments
In some cases, alternative management options may include:
- Observation for small, asymptomatic lesions.
- Cryotherapy for superficial lesions.
- Topical treatments for certain benign skin conditions.
Home Care Tips
Patients can follow these tips for effective home care:
- Keep the area clean and dry.
- Avoid picking at the wound or scabs.
- Use sunscreen on the healing area to prevent discoloration.
- Report any signs of infection to the healthcare provider.
Patient Education & Prevention
To prevent recurrence and promote skin health:
- Regular skin checks for new or changing lesions.
- Use sunscreen to protect skin from UV damage.
- Avoid excessive sun exposure, especially during peak hours.
- Maintain a healthy lifestyle to support skin health.
Billing and Coding Information
CPT Code: 21601
Category: Surgery
Common Modifiers:
- 50 - Bilateral procedure
- 59 - Distinct procedural service
Average Cost and Insurance Coverage
The cost for this procedure can vary widely:
- Average cost ranges from $500 to $2,000 depending on location and complexity.
- Most insurance plans cover excision of benign lesions if medically necessary.
- Patients should verify coverage details with their insurance provider.
Related CPT Codes
- 11406 - Excision, benign skin lesion; face, ears, scalp, neck, excised diameter over 4.0 cm
- 11400 - Excision, benign skin lesion, face, ears, scalp, neck; excised diameter over 4.0 cm.
- 11402 - Excision, benign skin lesion, face, ears, scalp, neck; excised diameter over 4.0 cm.
- 11404 - Excision, benign skin lesion, face, ears, scalp; excised diameter over 4.0 cm.
References and Sources