Overview of CPT Code 21480: Excision, tumor, soft tissue of neck or thorax
CPT Code 21480 refers to the surgical excision of a tumor located in the soft tissue of the neck or thorax. This procedure is typically performed to remove benign or malignant tumors, ensuring complete removal to prevent recurrence and to facilitate further pathological examination.
When CPT Code 21480 is Used?
This code is applicable in various clinical scenarios, including:
- Presence of a palpable tumor in the soft tissue of the neck or thorax.
- Suspicion of malignancy based on imaging or physical examination.
- Tumors causing symptoms such as pain or discomfort.
- Need for definitive diagnosis through histopathological examination.
Symptoms Indicating This Procedure
Patients may report the following symptoms that could necessitate this procedure:
- A noticeable lump or mass in the neck or thorax.
- Pain or tenderness in the area of the tumor.
- Changes in skin appearance over the tumor, such as discoloration.
- Difficulty swallowing or breathing if the tumor is compressing nearby structures.
Causes and Risk Factors
Several factors may contribute to the development of tumors in the soft tissue of the neck or thorax:
- Genetic predisposition to certain types of tumors.
- Previous history of cancer or tumors.
- Exposure to radiation or carcinogenic substances.
- Chronic inflammation or infection in the area.
Diagnostic Tests Before Procedure
Prior to the excision, several diagnostic tests may be conducted:
- Ultrasound imaging to assess the size and characteristics of the tumor.
- CT or MRI scans for detailed visualization of the tumor and surrounding structures.
- Biopsy to determine the nature of the tumor (benign or malignant).
- Blood tests to evaluate overall health and any underlying conditions.
Procedure Description
The excision procedure typically follows these steps:
- Patient is positioned comfortably and anesthetized.
- An incision is made over the tumor site, taking care to minimize damage to surrounding tissues.
- The tumor is carefully excised along with a margin of healthy tissue.
- The wound is cleaned and may be drained if necessary.
- The incision is closed with sutures or staples, and a sterile dressing is applied.
Preparation for the Procedure
Patients should follow these guidelines before the procedure:
- Avoid eating or drinking for at least 8 hours prior to surgery.
- Discuss any medications with the healthcare provider, especially blood thinners.
- Arrange for transportation to and from the procedure.
- Wear loose, comfortable clothing on the day of the procedure.
Recovery and Aftercare
Post-procedure recovery typically involves:
- Resting for the first 24 hours after surgery.
- Keeping the surgical site clean and dry.
- Monitoring for signs of infection, such as increased redness or discharge.
- Taking prescribed pain medications as needed.
- Follow-up appointment to remove sutures and assess healing.
Possible Complications
While generally safe, this procedure carries some risks, including:
- Infection at the surgical site.
- Excessive bleeding or hematoma formation.
- Scarring or changes in skin sensation.
- Recurrence of the tumor if not completely excised.


Secure, compliant, and built for trust
HIPAA-compliant and designed with privacy in mind, your patient’s data is protected. Focus on care while we safeguard your information.
Learn morePost-Procedure Follow-Up
Follow-up care is essential for monitoring recovery:
- Initial follow-up within 1-2 weeks to check the surgical site.
- Further appointments may be scheduled based on pathology results.
- Regular monitoring for any signs of tumor recurrence.
Alternative Treatments
In some cases, non-surgical options may be considered:
- Observation for benign tumors without symptoms.
- Radiation therapy for certain types of malignant tumors.
- Chemotherapy for systemic treatment of cancer.
Home Care Tips
Patients can follow these tips for effective home care:
- Keep the incision site clean and dry.
- Avoid strenuous activities for at least a week.
- Apply ice packs to reduce swelling if needed.
- Follow dietary recommendations if applicable.
Patient Education & Prevention
To reduce the risk of tumors, consider these points:
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
- Avoid known carcinogens and limit sun exposure.
- Regular check-ups for early detection of any abnormalities.
- Genetic counseling if there is a family history of tumors.
Billing and Coding Information
CPT Code: 21480
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- RT - Right side
- LT - Left side
Average Cost and Insurance Coverage
The cost of this procedure can vary widely:
- Average cost ranges from $2,000 to $5,000 depending on complexity.
- Insurance typically covers the procedure if deemed medically necessary.
- Out-of-pocket costs may apply depending on the insurance plan.
Related CPT Codes
References and Sources