Overview of CPT Code 21421: Excision of benign skin lesion, face, ears, scalp, neck
CPT Code 21421 refers to the surgical excision of benign skin lesions located on the face, ears, scalp, or neck. This procedure is typically performed to remove lesions that are non-cancerous but may cause cosmetic concerns or discomfort.
When CPT Code 21421 is Used?
This code is applicable in various clinical scenarios, including:
- Removal of benign moles or nevi that are bothersome or unsightly.
- Excision of seborrheic keratosis that may be irritated or inflamed.
- Surgical intervention for lipomas located on the face or neck.
- Treatment of dermatofibromas that are symptomatic or cosmetically undesirable.
Symptoms Indicating This Procedure
Patients may report the following symptoms that lead to the consideration of this procedure:
- Visible skin lesions that are growing or changing in appearance.
- Lesions that cause discomfort or irritation.
- Cosmetic concerns regarding the appearance of skin lesions.
- Itching or tenderness associated with the lesion.
Causes and Risk Factors
Several factors can contribute to the development of benign skin lesions, including:
- Genetic predisposition to skin lesions.
- Sun exposure leading to skin changes.
- Age-related skin changes resulting in benign growths.
- Hormonal changes that may influence skin lesions.
Diagnostic Tests Before Procedure
Before proceeding with the excision, the following diagnostic tests may be conducted:
- Physical examination of the lesion to assess size and characteristics.
- Dermatoscopy to evaluate the lesion's structure.
- Biopsy may be performed if there is uncertainty about the nature of the lesion.
Procedure Description
The excision procedure typically follows these steps:
- Patient is positioned comfortably and the area is cleaned.
- Local anesthesia is administered to numb the area.
- A surgical incision is made around the lesion.
- The lesion is carefully excised along with a margin of healthy tissue.
- The wound is closed with sutures or adhesive strips.
- Dressing is applied to protect the area.
Preparation for the Procedure
Patients should follow these guidelines before the procedure:
- Avoid blood thinners and certain medications as advised by the physician.
- Inform the doctor of any allergies or medical conditions.
- Arrive with clean skin, free of lotions or makeup.
- Arrange for transportation if sedation is used.
Recovery and Aftercare
Post-procedure recovery typically involves:
- Resting for the remainder of the day after the procedure.
- Keeping the surgical site clean and dry.
- Changing dressings as instructed by the healthcare provider.
- Taking prescribed pain medications as needed.
Possible Complications
While generally safe, potential complications may include:
- Infection at the surgical site.
- Scarring or changes in skin pigmentation.
- Delayed healing of the wound.
- Recurrence of the lesion.


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Learn morePost-Procedure Follow-Up
Follow-up care is essential for monitoring recovery:
- Schedule a follow-up appointment within 1-2 weeks to assess healing.
- Contact the healthcare provider if there are signs of infection.
- Discuss pathology results if a biopsy was performed.
Alternative Treatments
Non-surgical options may include:
- Topical treatments for superficial lesions.
- Cryotherapy for certain benign skin growths.
- Laser therapy for cosmetic concerns.
Home Care Tips
Patients can follow these tips for effective home care:
- Keep the area clean and dry.
- Avoid picking at the wound.
- Use sunscreen to protect the healing skin.
- Monitor for any changes or signs of infection.
Patient Education & Prevention
To prevent recurrence and promote skin health:
- Regular skin checks for new or changing lesions.
- Use sunscreen to protect against UV damage.
- Maintain a healthy lifestyle to support skin health.
- Consult a dermatologist for any concerns about skin changes.
Billing and Coding Information
CPT Code: 21421
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- 59 - Distinct procedural service
Average Cost and Insurance Coverage
The cost of the procedure can vary widely:
- Average cost ranges from $200 to $1,500 depending on complexity.
- Most insurance plans cover excision of benign lesions.
- Patients should verify coverage with their insurance provider.
Related CPT Codes
- 11400 - Excision, benign skin lesion, face, ears, scalp, neck; excised diameter over 4.0 cm.
- 11401 - Excision, benign skin lesion, face, ears, scalp, neck; excised diameter over 4.0 cm.
- 11402 - Excision, benign skin lesion, face, ears, scalp, neck; excised diameter over 4.0 cm.
- 11403 - Excision, benign skin lesion, face, ears, scalp; excised diameter over 4.0 cm.
- 11406 - Excision, benign skin lesion; face, ears, scalp, neck, excised diameter over 4.0 cm
References and Sources