Overview of CPT Code 21295: Injection of implantable drug delivery system
CPT Code 21295 refers to the injection of an implantable drug delivery system, which is a method used to administer medication directly into a specific area of the body over an extended period. This procedure is often utilized in pain management and chronic disease treatment.
When CPT Code 21295 is Used?
This procedure is indicated in various clinical scenarios.
- Management of chronic pain conditions.
- Treatment of certain cancers requiring localized drug delivery.
- Patients with severe spasticity or muscle disorders.
- Conditions requiring long-term medication administration.
Symptoms Indicating This Procedure
Patients may present with specific symptoms that warrant this procedure.
- Persistent pain not relieved by oral medications.
- Severe muscle spasms.
- Symptoms of localized disease requiring targeted therapy.
- Inability to manage symptoms with conventional treatments.
Causes and Risk Factors
Several factors may lead to the need for an implantable drug delivery system.
- Chronic pain syndromes such as fibromyalgia.
- Cancer diagnoses requiring palliative care.
- Neurological disorders like multiple sclerosis.
- Previous unsuccessful treatments for pain management.
Diagnostic Tests Before Procedure
Certain tests may be conducted to ensure the appropriateness of the procedure.
- Imaging studies such as MRI or CT scans.
- Blood tests to assess overall health.
- Pain assessments and questionnaires.
- Neurological evaluations.
Procedure Description
The procedure involves several key steps.
- Patient is positioned comfortably.
- Local anesthesia is administered to the site.
- A small incision is made to insert the drug delivery system.
- The device is placed and secured in the appropriate location.
- The incision is closed and dressed.
Preparation for the Procedure
Patients should follow specific guidelines before the procedure.
- Discuss all medications with the healthcare provider.
- Avoid blood thinners and certain supplements as advised.
- Arrive fasting if instructed.
- Arrange for transportation post-procedure.
Recovery and Aftercare
Post-procedure care is crucial for recovery.
- Rest for the first 24 hours.
- Keep the incision site clean and dry.
- Follow up with prescribed medications for pain management.
- Attend follow-up appointments for monitoring.
Possible Complications
As with any procedure, there are potential risks involved.
- Infection at the insertion site.
- Device malfunction or displacement.
- Allergic reactions to the medication.
- Nerve damage or pain at the site.


Secure, compliant, and built for trust
HIPAA-compliant and designed with privacy in mind, your patient’s data is protected. Focus on care while we safeguard your information.
Learn morePost-Procedure Follow-Up
Regular follow-up is essential for monitoring progress.
- Initial follow-up within one week post-procedure.
- Subsequent visits every few weeks to assess device function.
- Adjustments to medication as needed.
- Long-term monitoring for effectiveness and side effects.
Alternative Treatments
There are various non-surgical options available.
- Oral medications for pain management.
- Physical therapy and rehabilitation.
- Acupuncture and alternative therapies.
- Nerve blocks or other injection therapies.
Home Care Tips
Patients can take steps to aid their recovery at home.
- Monitor the incision site for signs of infection.
- Keep follow-up appointments.
- Engage in light activities as tolerated.
- Maintain a healthy diet to support healing.
Patient Education & Prevention
Education is key to preventing complications.
- Understand the purpose and function of the device.
- Recognize signs of complications early.
- Adhere to medication schedules.
- Engage in lifestyle modifications to manage underlying conditions.
Billing and Coding Information
CPT Code: 21295
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- LT - Left side
- RT - Right side
Average Cost and Insurance Coverage
Costs can vary based on several factors.
- Average cost ranges from $5,000 to $15,000.
- Insurance may cover a portion depending on the policy.
- Pre-authorization may be required for coverage.
- Out-of-pocket costs can vary significantly.
Related CPT Codes
References and Sources