Overview of CPT Code 21280: Injection of facial soft tissue
CPT Code 21280 refers to the injection of facial soft tissue, typically used for cosmetic enhancement or reconstruction. This procedure involves the administration of substances such as fillers or other agents to improve facial aesthetics or restore volume.
When CPT Code 21280 is Used?
This code is applicable in various clinical scenarios, including:
- Facial volume loss due to aging or weight loss.
- Correction of facial asymmetry.
- Enhancement of facial contours, such as cheeks or lips.
- Reconstruction after trauma or surgery.
- Treatment of certain medical conditions affecting facial appearance.
Symptoms Indicating This Procedure
Patients may report the following symptoms that indicate the need for this procedure:
- Sunken cheeks or temples.
- Thin or wrinkled lips.
- Facial asymmetry.
- Loss of skin elasticity.
- Deep nasolabial folds.
Causes and Risk Factors
Several factors can contribute to the need for facial soft tissue injections:
- Aging, leading to natural volume loss.
- Genetic predisposition to facial structure.
- Significant weight loss.
- Sun exposure causing skin damage.
- Certain medical conditions affecting skin and tissue.
Diagnostic Tests Before Procedure
Before the injection, the following assessments may be performed:
- Physical examination of facial structure.
- Assessment of skin quality and elasticity.
- Review of medical history and allergies.
- Photographic documentation for comparison.
Procedure Description
The injection procedure typically follows these steps:
- Patient consultation to discuss goals and expectations.
- Preparation of the injection site, including cleansing.
- Marking the areas for injection.
- Administering a local anesthetic if necessary.
- Injecting the chosen filler or substance into the designated areas.
- Massaging the area to ensure even distribution.
- Providing post-procedure instructions.
Preparation for the Procedure
Patients should follow these guidelines before the procedure:
- Avoid blood thinners such as aspirin or ibuprofen for a week prior.
- Refrain from alcohol consumption 24 hours before the procedure.
- Discuss any allergies or previous reactions to fillers with the provider.
- Arrive with a clean face, free of makeup.
Recovery and Aftercare
Post-procedure, patients can expect the following:
- Mild swelling and bruising at the injection site, typically resolving within a few days.
- Avoiding strenuous activities for 24-48 hours.
- Applying ice packs to reduce swelling.
- Following up with the provider if any unusual symptoms occur.
Possible Complications
While generally safe, potential complications include:
- Bruising and swelling.
- Infection at the injection site.
- Allergic reactions to the filler material.
- Asymmetry or uneven results.
- Vascular occlusion leading to tissue necrosis.


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Learn morePost-Procedure Follow-Up
Follow-up appointments are important for monitoring:
- Typically scheduled 1-2 weeks after the procedure.
- Assessment of results and any adjustments if necessary.
- Discussion of long-term care and maintenance.
Alternative Treatments
Patients may consider these non-surgical options:
- Topical fillers or creams for minor volume loss.
- Laser treatments for skin tightening.
- Chemical peels for skin texture improvement.
- Microneedling for collagen stimulation.
Home Care Tips
To aid recovery, patients should consider these tips:
- Keep the head elevated for the first night.
- Avoid touching or massaging the injection site.
- Stay hydrated and maintain a healthy diet.
- Use gentle skincare products to avoid irritation.
Patient Education & Prevention
To prevent complications and recurrence:
- Understand the risks and benefits of the procedure.
- Choose a qualified and experienced provider.
- Maintain a healthy lifestyle to support skin health.
- Regularly consult with a dermatologist for skin care.
Billing and Coding Information
CPT Code: 21280
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- RT - Right side
- LT - Left side
Average Cost and Insurance Coverage
The cost of this procedure can vary widely:
- Average cost ranges from $500 to $2,000 per session.
- Insurance may not cover cosmetic procedures.
- Check with your provider for specific coverage details.
Related CPT Codes
References and Sources