Overview of CPT Code 21235: Injection of implantable drug delivery system
CPT Code 21235 refers to the injection of an implantable drug delivery system, which is a medical procedure used to administer medication directly into a specific area of the body over an extended period. This method is often utilized in pain management and treatment of chronic conditions.
When CPT Code 21235 is Used?
This procedure is indicated in various clinical scenarios.
- Management of chronic pain conditions such as cancer pain.
- Treatment of severe spasticity in conditions like multiple sclerosis.
- Delivery of chemotherapy agents directly to a tumor site.
- Long-term management of certain neurological disorders.
Symptoms Indicating This Procedure
Patients may present with specific symptoms that warrant this procedure.
- Persistent pain that is unresponsive to oral medications.
- Severe muscle spasms or spasticity.
- Neuropathic pain symptoms.
- Symptoms of localized disease requiring targeted therapy.
Causes and Risk Factors
Several factors may lead to the need for an implantable drug delivery system.
- Chronic pain conditions.
- Neurological disorders.
- Cancer and related treatments.
- Previous surgeries that may have altered pain pathways.
Diagnostic Tests Before Procedure
Certain tests may be conducted to ensure the appropriateness of the procedure.
- MRI or CT scans to assess the area of treatment.
- Nerve conduction studies to evaluate nerve function.
- Blood tests to check for underlying conditions.
- Pain assessments and questionnaires.
Procedure Description
The procedure involves several key steps to ensure safety and efficacy.
- Obtain informed consent from the patient.
- Administer local anesthesia to the treatment area.
- Make a small incision to insert the drug delivery system.
- Position the device accurately for optimal drug delivery.
- Suture the incision site and apply a sterile dressing.
Preparation for the Procedure
Patients should follow specific guidelines before the procedure.
- Discuss all medications with the healthcare provider.
- Avoid blood thinners for a specified period before the procedure.
- Arrive at the facility with a responsible adult for post-procedure transport.
- Follow any fasting instructions if applicable.
Recovery and Aftercare
Post-procedure care is crucial for recovery.
- Rest for the first 24 hours post-procedure.
- Keep the incision site clean and dry.
- Monitor for signs of infection such as redness or swelling.
- Follow up with the healthcare provider as scheduled.
Possible Complications
As with any medical procedure, there are potential risks involved.
- Infection at the injection site.
- Bleeding or hematoma formation.
- Device malfunction or displacement.
- Allergic reactions to the medication.


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Learn morePost-Procedure Follow-Up
Regular follow-up is essential for monitoring progress.
- Initial follow-up within one week post-procedure.
- Subsequent visits every few weeks to assess pain relief and device function.
- Long-term follow-up as needed based on patient response.
Alternative Treatments
There are various non-surgical options available.
- Oral medications for pain management.
- Physical therapy and rehabilitation.
- Nerve blocks or epidural steroid injections.
- Acupuncture and alternative therapies.
Home Care Tips
Patients can take steps at home to aid recovery.
- Apply ice packs to the area to reduce swelling.
- Take prescribed medications as directed.
- Engage in light activities as tolerated.
- Avoid heavy lifting or strenuous activities for a few weeks.
Patient Education & Prevention
Education is key to preventing complications and recurrence.
- Understand the importance of medication adherence.
- Recognize signs of complications early.
- Maintain a healthy lifestyle to support overall health.
- Engage in regular follow-up appointments.
Billing and Coding Information
CPT Code: 21235
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- LT - Left side
- RT - Right side
Average Cost and Insurance Coverage
Costs can vary based on several factors.
- Average cost ranges from $5,000 to $15,000.
- Insurance may cover a portion depending on the policy.
- Pre-authorization may be required for coverage.
Related CPT Codes
References and Sources