Overview of CPT Code 20250:'Biopsy, skin, subcutaneous tissue, or mucous membrane'
CPT Code 20250 refers to a procedure where a small sample of skin, subcutaneous tissue, or mucous membrane is removed for diagnostic examination. This biopsy helps in identifying various skin conditions, including infections, inflammatory diseases, and cancers.
When CPT Code 20250 is Used?
This procedure is indicated in several clinical scenarios.
- Suspicion of skin cancer based on visual examination.
- Persistent skin lesions that do not respond to treatment.
- Unexplained skin changes or rashes.
- Evaluation of inflammatory skin diseases.
Symptoms Indicating This Procedure
Patients may report various symptoms that lead to the need for a biopsy.
- New or changing moles or skin lesions.
- Itching or pain in a specific area of the skin.
- Non-healing sores or ulcers.
- Redness or swelling around a lesion.
Causes and Risk Factors
Several factors can contribute to the need for a biopsy.
- Family history of skin cancer.
- Excessive sun exposure or tanning bed use.
- Weakened immune system.
- Previous skin conditions or lesions.
Diagnostic Tests Before Procedure
Certain tests may be conducted prior to the biopsy.
- Physical examination of the skin.
- Dermatoscopy to examine skin lesions closely.
- Blood tests if systemic conditions are suspected.
Procedure Description
The biopsy procedure involves several key steps.
- The area is cleaned and sterilized.
- Local anesthesia is administered to minimize discomfort.
- A small incision is made to remove a sample of tissue.
- The sample is sent to a laboratory for analysis.
- The incision is closed with stitches or adhesive.
Preparation for the Procedure
Patients should follow specific guidelines before the biopsy.
- Avoid blood thinners or certain medications as advised by the doctor.
- Inform the doctor about any allergies.
- Arrive with clean skin, free of lotions or creams.
Recovery and Aftercare
Post-procedure care is essential for healing.
- Keep the biopsy site clean and dry.
- Change dressings as instructed.
- Avoid strenuous activities for a few days.
- Follow up for stitch removal if applicable.
Possible Complications
While generally safe, there are potential risks.
- Infection at the biopsy site.
- Excessive bleeding.
- Scarring or changes in skin pigmentation.
- Allergic reaction to anesthesia.


Secure, compliant, and built for trust
HIPAA-compliant and designed with privacy in mind, your patient’s data is protected. Focus on care while we safeguard your information.
Learn morePost-Procedure Follow-Up
Monitoring after the procedure is crucial.
- Schedule a follow-up appointment to discuss biopsy results.
- Monitor the biopsy site for signs of infection.
- Report any unusual symptoms to the healthcare provider.
Alternative Treatments
There are non-surgical options for skin conditions.
- Topical medications for inflammatory skin diseases.
- Cryotherapy for certain skin lesions.
- Phototherapy for psoriasis or eczema.
Home Care Tips
Patients can take steps to aid recovery at home.
- Keep the biopsy area clean and dry.
- Avoid picking at scabs or lesions.
- Use over-the-counter pain relief as needed.
Patient Education & Prevention
Educating patients can help prevent skin issues.
- Regular skin checks for new or changing lesions.
- Use sunscreen to protect against UV damage.
- Avoid tanning beds and excessive sun exposure.
Billing and Coding Information
CPT Code: 20250
Category: Surgical Procedures
Common Modifiers:
- 25 - Significant, separately identifiable evaluation and management service by the same physician on the same day of the procedure.
- 59 - Distinct procedural service.
Average Cost and Insurance Coverage
Costs can vary based on location and insurance.
- Average cost ranges from $200 to $500.
- Most insurance plans cover medically necessary biopsies.
- Check with your insurance provider for specific coverage details.
Related CPT Codes
References and Sources