Overview of CPT Code 19281: Breast Biopsy, Needle, Percutaneous
CPT Code 19281 refers to a percutaneous needle biopsy of the breast, a minimally invasive procedure used to obtain tissue samples for diagnostic evaluation of breast abnormalities.
When CPT Code 19281 is Used?
This procedure is indicated in various clinical scenarios.
- Suspicious breast mass detected on imaging studies.
- Abnormal findings on a clinical breast exam.
- Follow-up of previously identified breast lesions.
- Assessment of breast tissue in patients with a family history of breast cancer.
Symptoms Indicating This Procedure
Patients may report several symptoms that warrant a breast biopsy.
- Palpable lump or mass in the breast.
- Changes in breast shape or size.
- Nipple discharge that is bloody or clear.
- Skin changes over the breast, such as dimpling or puckering.
Causes and Risk Factors
Several factors may contribute to the need for a breast biopsy.
- Family history of breast cancer.
- Genetic mutations such as BRCA1 or BRCA2.
- Previous breast biopsies with atypical results.
- Age, with increased risk in women over 40.
Diagnostic Tests Before Procedure
Prior to the biopsy, several diagnostic tests may be performed.
- Mammography to identify abnormalities.
- Ultrasound to evaluate breast masses.
- MRI for detailed imaging of breast tissue.
- Fine needle aspiration cytology for preliminary assessment.
Procedure Description
The procedure involves several key steps.
- Patient is positioned comfortably, usually lying on their back.
- The area of the breast is cleaned and sterilized.
- Local anesthesia is administered to numb the area.
- A thin needle is inserted into the breast tissue to obtain a sample.
- Multiple samples may be taken to ensure adequate tissue for diagnosis.
- The needle is removed, and pressure is applied to minimize bleeding.
Preparation for the Procedure
Patients should follow specific guidelines before the biopsy.
- Avoid blood thinners for several days prior to the procedure.
- Inform the physician of any allergies, especially to anesthetics.
- Wear comfortable clothing and avoid wearing deodorant or lotions on the day of the procedure.
- Arrange for transportation home if sedation is used.
Recovery and Aftercare
Post-procedure care is essential for recovery.
- Rest for the remainder of the day after the procedure.
- Apply ice packs to reduce swelling and discomfort.
- Keep the biopsy site clean and dry; follow specific wound care instructions.
- Over-the-counter pain relievers may be used as needed.
Possible Complications
While generally safe, there are potential risks associated with the procedure.
- Bleeding at the biopsy site.
- Infection at the site of the biopsy.
- Hematoma formation (a localized collection of blood).
- Discomfort or pain in the breast area.


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Learn morePost-Procedure Follow-Up
Follow-up care is crucial for monitoring recovery.
- Schedule a follow-up appointment within one week to discuss biopsy results.
- Monitor the biopsy site for signs of infection or excessive swelling.
- Report any unusual symptoms, such as fever or increased pain, to the physician.
Alternative Treatments
There are non-surgical options for managing breast abnormalities.
- Regular monitoring with imaging studies for benign lesions.
- Medications for hormonal therapy in certain breast conditions.
- Lifestyle changes, including diet and exercise, to reduce breast cancer risk.
Home Care Tips
Patients can take steps to aid their recovery at home.
- Keep the biopsy site clean and dry.
- Avoid strenuous activities for a few days.
- Wear a supportive bra to minimize discomfort.
- Stay hydrated and maintain a balanced diet.
Patient Education & Prevention
Education is key to preventing breast health issues.
- Perform regular breast self-exams to detect changes early.
- Schedule routine mammograms as recommended by your physician.
- Discuss family history and risk factors with your healthcare provider.
- Adopt a healthy lifestyle to reduce overall cancer risk.
Billing and Coding Information
CPT Code: 19281
Category: Surgical Procedures
Common Modifiers:
- 50 (bilateral procedure)
- LT (left side)
- RT (right side)
Average Cost and Insurance Coverage
Costs can vary based on location and insurance.
- Average cost ranges from $1,000 to $3,000.
- Most insurance plans cover the procedure if deemed medically necessary.
- Patients should verify coverage details with their insurance provider.
Related CPT Codes
References and Sources