Overview of CPT Code 19221: Breast Biopsy, Needle, Percutaneous
CPT Code 19221 refers to a percutaneous needle biopsy of the breast, a minimally invasive procedure used to obtain tissue samples for diagnostic evaluation of breast abnormalities.
When CPT Code 19221 is Used?
This procedure is indicated in various clinical scenarios.
- Suspicious breast mass detected on imaging studies.
- Abnormal findings on a clinical breast exam.
- Follow-up of previously identified breast lesions.
- Assessment of breast tissue in patients with a family history of breast cancer.
Symptoms Indicating This Procedure
Patients may report several symptoms that warrant a biopsy.
- Palpable lump or mass in the breast.
- Changes in breast shape or size.
- Nipple discharge that is bloody or clear.
- Skin changes over the breast, such as dimpling or puckering.
Causes and Risk Factors
Several factors may contribute to the need for a breast biopsy.
- Family history of breast cancer.
- Genetic mutations such as BRCA1 or BRCA2.
- Previous breast biopsies with atypical results.
- Age, with increased risk in women over 40.
Diagnostic Tests Before Procedure
Prior to the biopsy, certain tests may be performed.
- Mammography to identify abnormalities.
- Ultrasound to evaluate the characteristics of a breast mass.
- MRI for detailed imaging of breast tissue.
- Fine needle aspiration cytology if indicated.
Procedure Description
The procedure involves several key steps.
- Patient is positioned comfortably, usually lying on their back.
- Skin over the biopsy site is cleaned and numbed with local anesthesia.
- A thin needle is inserted into the breast tissue to obtain a sample.
- Ultrasound or mammography may be used to guide the needle.
- Multiple samples may be taken to ensure adequate tissue for diagnosis.
Preparation for the Procedure
Patients should follow specific guidelines before the biopsy.
- Avoid blood thinners for several days prior to the procedure.
- Inform the physician of any allergies, especially to anesthetics.
- Wear comfortable clothing and avoid wearing deodorant or lotions on the day of the procedure.
- Arrange for transportation home if sedation is used.
Recovery and Aftercare
Post-procedure care is essential for recovery.
- Rest for the remainder of the day after the procedure.
- Apply ice packs to reduce swelling and discomfort.
- Keep the biopsy site clean and dry; follow specific wound care instructions.
- Over-the-counter pain relievers may be used as needed.
Possible Complications
While generally safe, some risks are associated with the procedure.
- Bleeding or bruising at the biopsy site.
- Infection at the site of the biopsy.
- Discomfort or pain following the procedure.
- Possible changes in breast appearance.


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Learn morePost-Procedure Follow-Up
Monitoring after the procedure is important.
- Schedule a follow-up appointment to discuss biopsy results.
- Monitor for any signs of infection or complications.
- Regular breast exams as recommended by the healthcare provider.
Alternative Treatments
Other management options may be considered.
- Watchful waiting for benign findings.
- Medication for hormonal therapy in certain cases.
- Surgical excision if indicated based on biopsy results.
Home Care Tips
Patients can take steps to aid recovery at home.
- Avoid strenuous activities for a few days post-procedure.
- Keep the biopsy site clean and dry.
- Monitor for any unusual symptoms and contact a healthcare provider if they occur.
- Follow all post-procedure instructions provided by the healthcare team.
Patient Education & Prevention
Education is key to prevention and early detection.
- Regular breast self-exams to detect changes early.
- Routine mammograms as recommended based on age and risk factors.
- Healthy lifestyle choices to reduce breast cancer risk.
- Genetic counseling for those with a family history of breast cancer.
Billing and Coding Information
CPT Code: 19221
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- RT - Right side
- LT - Left side
Average Cost and Insurance Coverage
Costs can vary based on location and insurance.
- Average cost ranges from $1,000 to $3,000.
- Most insurance plans cover the procedure if deemed medically necessary.
- Patients should verify coverage with their insurance provider.
Related CPT Codes
References and Sources