Overview of CPT Code 15983: Injection of Biologic Agent into Tumor
CPT Code 15983 refers to the procedure of injecting a biologic agent directly into a tumor. This treatment is often used in oncology to target cancer cells more effectively, enhancing the immune response and potentially shrinking tumors.
When CPT Code 15983 is Used?
This procedure is indicated in various clinical scenarios.
- Patients with solid tumors that are not amenable to surgical resection.
- Tumors that have shown resistance to conventional therapies.
- Patients seeking localized treatment to minimize systemic side effects.
Symptoms Indicating This Procedure
Patients may present with specific symptoms that warrant this procedure.
- Localized pain or discomfort in the area of the tumor.
- Visible swelling or mass in the affected region.
- Symptoms related to tumor growth, such as obstruction or pressure on surrounding organs.
Causes and Risk Factors
Understanding the underlying causes and risk factors is crucial.
- Genetic predisposition to certain types of cancer.
- Environmental exposures, such as radiation or carcinogenic substances.
- Chronic inflammation or infection that may lead to tumor development.
Diagnostic Tests Before Procedure
Several diagnostic tests may be performed prior to the injection.
- Imaging studies such as CT or MRI to assess tumor size and location.
- Biopsy to confirm the type of tumor and its responsiveness to biologic agents.
- Blood tests to evaluate overall health and organ function.
Procedure Description
The procedure involves several key steps.
- Patient is positioned comfortably, and the area around the tumor is cleaned.
- Local anesthesia may be administered to minimize discomfort.
- A syringe containing the biologic agent is carefully injected into the tumor.
- The injection site is monitored for any immediate reactions.
Preparation for the Procedure
Proper preparation is essential for a successful procedure.
- Patients should inform their doctor of any medications they are taking.
- Fasting may be required for a few hours before the procedure.
- Patients should arrange for transportation home post-procedure.
Recovery and Aftercare
Post-procedure care is important for recovery.
- Patients can expect mild soreness at the injection site.
- Ice packs may be applied to reduce swelling.
- Follow-up appointments should be scheduled to monitor the treatment's effectiveness.
Possible Complications
While generally safe, there are potential risks involved.
- Infection at the injection site.
- Allergic reactions to the biologic agent.
- Localized bleeding or bruising.


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Learn morePost-Procedure Follow-Up
Monitoring after the procedure is crucial.
- Follow-up visits are typically scheduled within 1-2 weeks.
- Imaging may be repeated to assess tumor response.
- Patients should report any unusual symptoms immediately.
Alternative Treatments
There are other treatment options available.
- Chemotherapy to target cancer cells systemically.
- Radiation therapy to shrink tumors.
- Immunotherapy to enhance the body's immune response.
Home Care Tips
Patients can take steps to aid their recovery at home.
- Keep the injection site clean and dry.
- Avoid strenuous activities for a few days.
- Stay hydrated and maintain a balanced diet.
Patient Education & Prevention
Education is key to prevention and managing recurrence.
- Regular screenings for early detection of tumors.
- Healthy lifestyle choices to reduce cancer risk.
- Awareness of family history and genetic counseling if necessary.
Billing and Coding Information
CPT Code: 15983
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- LT - Left side
- RT - Right side
Average Cost and Insurance Coverage
Costs can vary based on several factors.
- The average cost ranges from $1,500 to $3,000.
- Most insurance plans cover this procedure, but prior authorization may be required.
- Out-of-pocket costs depend on the patient's insurance plan.
Related CPT Codes
References and Sources