Overview of CPT Code 15777: Injection of biologics into soft tissue
CPT Code 15777 refers to the injection of biologics into soft tissue, a procedure used to deliver therapeutic agents directly into affected areas to promote healing and reduce inflammation.
When CPT Code 15777 is Used?
This procedure is indicated in various clinical scenarios.
- Chronic tendonitis or tendinopathy
- Osteoarthritis in joints
- Soft tissue injuries requiring localized treatment
- Plantar fasciitis
- Bursitis
Symptoms Indicating This Procedure
Patients may report several symptoms that warrant this procedure.
- Localized pain in the affected area
- Swelling and inflammation
- Reduced range of motion
- Tenderness to touch
- Stiffness in the joint or soft tissue
Causes and Risk Factors
Understanding the underlying causes can help in managing conditions effectively.
- Overuse injuries from repetitive activities
- Age-related degeneration of tissues
- Previous injuries or trauma
- Obesity increasing joint stress
- Certain medical conditions like diabetes or rheumatoid arthritis
Diagnostic Tests Before Procedure
Several tests may be conducted to confirm the need for this injection.
- X-rays to assess joint damage
- MRI to evaluate soft tissue structures
- Ultrasound for real-time imaging of the injection site
- Blood tests to rule out infections or inflammatory conditions
Procedure Description
The injection procedure is straightforward and typically performed in an outpatient setting.
- Patient is positioned comfortably.
- The injection site is cleaned with antiseptic.
- Local anesthesia may be administered to minimize discomfort.
- The biologic agent is drawn into a syringe.
- The needle is inserted into the targeted soft tissue.
- The biologic is injected slowly.
- The needle is withdrawn, and a bandage is applied.
Preparation for the Procedure
Proper preparation can enhance the effectiveness of the procedure.
- Discuss any allergies with your healthcare provider.
- Inform the provider about current medications, especially blood thinners.
- Avoid anti-inflammatory medications for a few days prior.
- Wear loose-fitting clothing to allow easy access to the injection site.
Recovery and Aftercare
Post-procedure care is essential for optimal recovery.
- Rest the injected area for 24-48 hours.
- Apply ice to reduce swelling.
- Avoid strenuous activities for a few days.
- Follow up with your healthcare provider as advised.
- Monitor for any signs of infection or unusual pain.
Possible Complications
While generally safe, there are potential risks associated with the procedure.
- Infection at the injection site
- Allergic reaction to the injected substance
- Increased pain or swelling
- Nerve or tissue damage
- Bleeding or bruising


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Learn morePost-Procedure Follow-Up
Regular follow-up is crucial to assess recovery and effectiveness.
- Initial follow-up within one week post-injection.
- Further assessments at 2-4 weeks to evaluate response.
- Long-term follow-up may be necessary for chronic conditions.
Alternative Treatments
There are several non-surgical options available.
- Physical therapy to strengthen and rehabilitate the area.
- Corticosteroid injections for inflammation.
- Oral anti-inflammatory medications.
- Rest and activity modification.
- Acupuncture or massage therapy.
Home Care Tips
Simple home care can aid in recovery.
- Keep the injection site clean and dry.
- Use ice packs to manage swelling.
- Engage in gentle stretching exercises as tolerated.
- Stay hydrated and maintain a balanced diet.
- Follow any specific instructions from your healthcare provider.
Patient Education & Prevention
Education is key to preventing recurrence.
- Understand the importance of proper warm-up before activities.
- Incorporate strength training to support joints.
- Maintain a healthy weight to reduce joint stress.
- Avoid repetitive strain on vulnerable areas.
- Seek early treatment for injuries to prevent chronic issues.
Billing and Coding Information
CPT Code: 15777
Category: Surgical Procedures
Common Modifiers:
- 50 - Bilateral procedure
- RT - Right side
- LT - Left side
Average Cost and Insurance Coverage
Costs can vary based on location and insurance.
- Average cost ranges from $300 to $800 per injection.
- Insurance may cover the procedure if deemed medically necessary.
- Check with your insurance provider for specific coverage details.
Related CPT Codes
References and Sources