Overview of CPT Code 11101:biopsy-of-skin-excisional-single-lesion
CPT Code 11101 refers to the excisional biopsy of a single skin lesion, a procedure used to remove a portion or all of a suspicious skin area for diagnostic evaluation.
When CPT Code 11101 is Used?
This procedure is indicated in various clinical scenarios.
- Presence of a suspicious mole or skin lesion that may be cancerous.
- Lesions that have changed in size, shape, or color.
- Persistent skin growths that do not respond to other treatments.
- Skin lesions that require histological examination for diagnosis.
Symptoms Indicating This Procedure
Patients may report several symptoms prompting the need for an excisional biopsy.
- A mole or skin lesion that appears irregular or asymmetrical.
- Itching, bleeding, or crusting of a skin lesion.
- Changes in the color or texture of a mole.
- A new growth on the skin that is concerning to the patient.
Causes and Risk Factors
Several factors can contribute to the development of skin lesions.
- Excessive sun exposure leading to skin damage.
- Family history of skin cancer.
- Fair skin or light-colored hair and eyes.
- Previous history of skin cancer or atypical moles.
Diagnostic Tests Before Procedure
Certain tests may be conducted to assess the lesion before the biopsy.
- Physical examination of the skin lesion.
- Dermatoscopy to visualize the lesion in detail.
- Imaging studies if the lesion is suspected to be deeper than the skin.
Procedure Description
The excisional biopsy procedure involves several key steps.
- The patient is positioned comfortably, and the area around the lesion is cleaned.
- Local anesthesia is administered to numb the area.
- A scalpel is used to excise the lesion along with a margin of healthy skin.
- The wound is closed with sutures or adhesive strips, and a sterile dressing is applied.
Preparation for the Procedure
Patients should follow specific guidelines before the biopsy.
- Avoid blood-thinning medications like aspirin or ibuprofen for a few days prior.
- Inform the doctor about any allergies, especially to anesthetics.
- Arrive with clean skin and avoid applying lotions or creams on the day of the procedure.
Recovery and Aftercare
Post-procedure care is essential for proper healing.
- Expect some swelling and tenderness at the biopsy site for a few days.
- Keep the area clean and dry; follow specific wound care instructions.
- Pain relief can be managed with over-the-counter medications as needed.
- Attend follow-up appointments to monitor healing and discuss biopsy results.
Possible Complications
While generally safe, there are potential risks associated with the procedure.
- Infection at the biopsy site.
- Excessive bleeding or hematoma formation.
- Scarring or changes in skin pigmentation.
- Allergic reaction to anesthesia.


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Learn morePost-Procedure Follow-Up
Follow-up care is crucial for monitoring recovery.
- A follow-up appointment is typically scheduled within 1-2 weeks to remove sutures and discuss results.
- Patients should report any signs of infection or unusual changes in the biopsy site.
Alternative Treatments
There are non-surgical options for managing skin lesions.
- Topical treatments for benign skin lesions.
- Cryotherapy to freeze off certain types of lesions.
- Laser therapy for cosmetic concerns or superficial lesions.
Home Care Tips
Patients can take steps to care for themselves post-procedure.
- Keep the biopsy site clean and dry.
- Avoid picking at the scab or lesion.
- Use sunscreen on the area once healed to prevent discoloration.
Patient Education & Prevention
Education is key to preventing skin lesions.
- Regular skin checks for new or changing lesions.
- Use sunscreen daily to protect against UV damage.
- Avoid tanning beds and excessive sun exposure.
Billing and Coding Information
CPT Code: 11101
Category: Surgical Procedures
Common Modifiers:
Average Cost and Insurance Coverage
Costs can vary based on location and insurance.
- The average cost of an excisional biopsy ranges from $200 to $1,000.
- Most insurance plans cover the procedure if deemed medically necessary.
Related CPT Codes
- 11100 - Biopsy of skin, single lesion
- 11400 - Excision, benign skin lesion, face, ears, scalp, neck; excised diameter over 4.0 cm.
- 11401 - Excision, benign skin lesion, face, ears, scalp, neck; excised diameter over 4.0 cm.
- 11402 - Excision, benign skin lesion, face, ears, scalp, neck; excised diameter over 4.0 cm.
- 11403 - Excision, benign skin lesion, face, ears, scalp; excised diameter over 4.0 cm.
- 11406 - Excision, benign skin lesion; face, ears, scalp, neck, excised diameter over 4.0 cm
References and Sources